Drug interactions
Felodipine + Isradipine
Severity: Moderate
Felodipine and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds hypotension, edema and reflex tachycardia without clear benefit.
What this interaction means in plain words
Felodipine and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive L-type calcium channel blockade and vasodilation.
What to do
Avoid combining two dihydropyridines; use a single agent or add a drug from another class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Isradipine?
MediHelp rates the interaction as moderate. Felodipine and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers, so combining them duplicates therapy and adds hypotension, edema and reflex tachycardia without clear benefit.
How serious is the interaction between Felodipine and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines; use a single agent or add a drug from another class.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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