Drug interactions
Felodipine + Lithium
Severity: Moderate
Felodipine and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Case reports describe neurotoxicity such as confusion, tremor and ataxia when calcium channel blockers are combined with lithium, sometimes with normal serum lithium levels. The reports are mostly with verapamil and diltiazem, and dihydropyridines are less often implicated. The interaction is rare but potentially significant.
What this interaction means in plain words
Felodipine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Why it happens
Mechanism is not established; possible additive effects on neuronal calcium handling.
What to do
Monitor for neurological symptoms and check lithium levels when starting felodipine. Reduce or stop either drug if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Felodipine with Lithium?
MediHelp rates the interaction as moderate. Felodipine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Case reports describe neurotoxicity such as confusion, tremor and ataxia when calcium channel blockers are combined with lithium, sometimes with normal serum lithium levels. The reports are mostly with verapamil and diltiazem, and dihydropyridines are less often implicated. The interaction is rare but potentially significant.
How serious is the interaction between Felodipine and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurological symptoms and check lithium levels when starting felodipine. Reduce or stop either drug if toxicity appears.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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