Drug interactions
Felodipine + Marijuana
Severity: Minor
Felodipine and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol may inhibit CYP3A4 and could raise felodipine concentrations. This may lead to stronger blood pressure lowering, flushing, headache or peripheral edema. Cannabis smoking also causes tachycardia and postural hypotension, which may add to the effect.
What this interaction means in plain words
Felodipine and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Cannabinoids (notably cannabidiol) may weakly inhibit CYP3A4-mediated felodipine metabolism, with additive hemodynamic effects.
What to do
Monitor blood pressure and heart rate in patients who use cannabis regularly and counsel on dizziness on standing. Reduce the felodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Felodipine and Marijuana, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Marijuana?
MediHelp rates the interaction as minor. Felodipine and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabinoids such as cannabidiol may inhibit CYP3A4 and could raise felodipine concentrations. This may lead to stronger blood pressure lowering, flushing, headache or peripheral edema. Cannabis smoking also causes tachycardia and postural hypotension, which may add to the effect.
How serious is the interaction between Felodipine and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate in patients who use cannabis regularly and counsel on dizziness on standing. Reduce the felodipine dose if hypotension or edema develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
