Drug interactions
Felodipine + Metformin-sitagliptin
Severity: Minor
Felodipine and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydropyridine calcium channel blockers have been reported to cause small increases in blood glucose in some patients, but the effect is generally minor. Clinically significant loss of glycemic control is uncommon.
What this interaction means in plain words
Felodipine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Calcium channel blockade may modestly reduce insulin secretion, a weak effect that opposes antidiabetic therapy.
What to do
No dose change is normally required; review glucose readings if control worsens after felodipine is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Felodipine and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydropyridine calcium channel blockers have been reported to cause small increases in blood glucose in some patients, but the effect is generally minor. Clinically significant loss of glycemic control is uncommon.
How serious is the interaction between Felodipine and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally required; review glucose readings if control worsens after felodipine is started.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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