Drug interactions
Felodipine + Miconazole vaginal
Severity: Moderate
Felodipine and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP3A4 inhibitor, and vaginal use gives low but measurable systemic absorption. Felodipine exposure could rise, causing hypotension, flushing and peripheral edema, particularly with repeated or prolonged courses.
What this interaction means in plain words
Felodipine and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Absorbed miconazole inhibits CYP3A4, reducing first-pass and systemic metabolism of felodipine.
What to do
Monitor blood pressure and edema during and after the miconazole course. Consider reducing the felodipine dose if hypotensive symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Miconazole vaginal?
MediHelp rates the interaction as moderate. Felodipine and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole is a CYP3A4 inhibitor, and vaginal use gives low but measurable systemic absorption. Felodipine exposure could rise, causing hypotension, flushing and peripheral edema, particularly with repeated or prolonged courses.
How serious is the interaction between Felodipine and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during and after the miconazole course. Consider reducing the felodipine dose if hypotensive symptoms appear.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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