Drug interactions
Felodipine + Midazolam intranasal
Severity: Moderate
Felodipine and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure. This could lengthen sedation after intranasal dosing. Midazolam can also lower blood pressure, adding to the effect of felodipine.
What this interaction means in plain words
Felodipine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak inhibition of CYP3A4 by felodipine reduces midazolam clearance, with additive hypotensive effects.
What to do
Monitor sedation level, respiratory status and blood pressure after dosing, and allow a longer observation period before discharge or resumption of activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Midazolam intranasal?
MediHelp rates the interaction as moderate. Felodipine and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is a weak CYP3A4 inhibitor and may modestly raise midazolam exposure. This could lengthen sedation after intranasal dosing. Midazolam can also lower blood pressure, adding to the effect of felodipine.
How serious is the interaction between Felodipine and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, respiratory status and blood pressure after dosing, and allow a longer observation period before discharge or resumption of activities.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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