Drug interactions
Felodipine + Nirmatrelvir
Severity: Major
Felodipine and Nirmatrelvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can greatly increase felodipine exposure. This may cause marked hypotension, edema and reflex tachycardia during the five-day course and shortly after.
What this interaction means in plain words
Felodipine and Nirmatrelvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Felodipine belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.
Why it happens
Ritonavir in the nirmatrelvir combination inhibits CYP3A4, reducing felodipine metabolism.
What to do
Consider a temporary felodipine dose reduction or hold during treatment, and monitor blood pressure. Resume the usual dose a few days after the course ends.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Felodipine with Nirmatrelvir?
MediHelp rates the interaction as major. Felodipine and Nirmatrelvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nirmatrelvir is boosted with ritonavir, a strong CYP3A4 inhibitor, which can greatly increase felodipine exposure. This may cause marked hypotension, edema and reflex tachycardia during the five-day course and shortly after.
How serious is the interaction between Felodipine and Nirmatrelvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a temporary felodipine dose reduction or hold during treatment, and monitor blood pressure. Resume the usual dose a few days after the course ends.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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