Drug interactions
Felodipine + Nitroglycerin rectal
Severity: Moderate
Felodipine and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates and calcium channel blockers both dilate vessels, and together they can cause marked orthostatic hypotension, dizziness and syncope. The combination is sometimes used deliberately in angina, but the blood pressure effect needs attention.
What this interaction means in plain words
Felodipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation via nitric oxide-mediated venous relaxation and calcium channel blockade of arterial smooth muscle.
What to do
Monitor blood pressure and orthostatic symptoms, particularly after starting or increasing a dose. Advise patients to change position slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Felodipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates and calcium channel blockers both dilate vessels, and together they can cause marked orthostatic hypotension, dizziness and syncope. The combination is sometimes used deliberately in angina, but the blood pressure effect needs attention.
How serious is the interaction between Felodipine and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly after starting or increasing a dose. Advise patients to change position slowly.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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