Drug interactions
Felodipine + Nitroglycerin sublingual
Severity: Moderate
Felodipine and Nitroglycerin sublingual: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower vascular tone through different pathways, so combined use can cause additive hypotension. Dizziness, syncope and orthostatic hypotension may occur, particularly after a sublingual nitroglycerin dose.
What this interaction means in plain words
Felodipine and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation: calcium channel blockade of arterial smooth muscle plus nitric oxide-mediated venodilation.
What to do
Advise patients to sit when taking sublingual nitroglycerin and to rise slowly. Monitor blood pressure and adjust felodipine if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Nitroglycerin sublingual?
MediHelp rates the interaction as moderate. Felodipine and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower vascular tone through different pathways, so combined use can cause additive hypotension. Dizziness, syncope and orthostatic hypotension may occur, particularly after a sublingual nitroglycerin dose.
How serious is the interaction between Felodipine and Nitroglycerin sublingual?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to sit when taking sublingual nitroglycerin and to rise slowly. Monitor blood pressure and adjust felodipine if symptomatic hypotension occurs.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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