Drug interactions
Felodipine + Nitroprusside
Severity: Moderate
Felodipine and Nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroprusside is a potent intravenous vasodilator, and felodipine adds to the blood pressure reduction. Excessive hypotension can occur, so infusion rates may need to be lower.
What this interaction means in plain words
Felodipine and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide release (nitroprusside) and calcium channel blockade (felodipine).
What to do
Titrate the nitroprusside infusion against continuous blood pressure monitoring, and expect lower dose requirements in patients taking felodipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Nitroprusside?
MediHelp rates the interaction as moderate. Felodipine and Nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroprusside is a potent intravenous vasodilator, and felodipine adds to the blood pressure reduction. Excessive hypotension can occur, so infusion rates may need to be lower.
How serious is the interaction between Felodipine and Nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the nitroprusside infusion against continuous blood pressure monitoring, and expect lower dose requirements in patients taking felodipine.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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