Drug interactions
Felodipine + Olanzapine / samidorphan
Severity: Moderate
Felodipine and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering effect of felodipine. Dizziness, syncope and falls are the main concerns, especially at initiation or dose increases.
What this interaction means in plain words
Felodipine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotension from olanzapine alpha-1 adrenergic antagonism and felodipine vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating olanzapine. Reduce felodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Felodipine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension and may add to the blood pressure lowering effect of felodipine. Dizziness, syncope and falls are the main concerns, especially at initiation or dose increases.
How serious is the interaction between Felodipine and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating olanzapine. Reduce felodipine dose if hypotension develops.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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