Drug interactions
Felodipine + Paclitaxel protein bound
Severity: Minor
Felodipine and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may weakly inhibit P-glycoprotein and CYP pathways involved in paclitaxel handling, which could theoretically increase paclitaxel exposure. No clinically significant effect has been well documented.
What this interaction means in plain words
Felodipine and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-glycoprotein inhibition by felodipine; no established clinical effect on paclitaxel clearance.
What to do
No dose change is needed. Monitor for paclitaxel toxicity such as neutropenia and neuropathy as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Felodipine and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine may weakly inhibit P-glycoprotein and CYP pathways involved in paclitaxel handling, which could theoretically increase paclitaxel exposure. No clinically significant effect has been well documented.
How serious is the interaction between Felodipine and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for paclitaxel toxicity such as neutropenia and neuropathy as usual.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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