Drug interactions
Felodipine + Penbutolol
Severity: Minor
Felodipine and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a dihydropyridine calcium channel blocker with a beta-blocker is common and usually beneficial, but blood pressure lowering is additive. Occasionally hypotension, bradycardia or heart failure symptoms may occur.
What this interaction means in plain words
Felodipine and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects through vasodilation and beta-adrenergic blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Adjust doses if symptomatic hypotension or bradycardia appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Penbutolol?
MediHelp rates the interaction as minor. Felodipine and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a dihydropyridine calcium channel blocker with a beta-blocker is common and usually beneficial, but blood pressure lowering is additive. Occasionally hypotension, bradycardia or heart failure symptoms may occur.
How serious is the interaction between Felodipine and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Adjust doses if symptomatic hypotension or bradycardia appears.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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