Drug interactions
Felodipine + Prazosin
Severity: Moderate
Felodipine and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure by vasodilation, so combining them can produce additive hypotension. First-dose or dose-increase orthostatic hypotension and syncope with prazosin may be more pronounced.
What this interaction means in plain words
Felodipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation from calcium channel blockade and alpha-1 adrenergic blockade.
What to do
Monitor blood pressure including orthostatic readings when starting or titrating either drug. Introduce the added agent at a low dose, ideally at bedtime.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Felodipine with Prazosin?
MediHelp rates the interaction as moderate. Felodipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure by vasodilation, so combining them can produce additive hypotension. First-dose or dose-increase orthostatic hypotension and syncope with prazosin may be more pronounced.
How serious is the interaction between Felodipine and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic readings when starting or titrating either drug. Introduce the added agent at a low dose, ideally at bedtime.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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