Drug interactions
Felodipine + Propranolol
Severity: Minor
Felodipine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol and felodipine have additive blood pressure lowering effects, which can be useful but may cause excessive hypotension, dizziness or peripheral edema. Propranolol may also modestly raise felodipine exposure.
What this interaction means in plain words
Felodipine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Felodipine belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects, with possible reduced hepatic blood flow slowing felodipine clearance.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Reduce the dose of felodipine if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Propranolol?
MediHelp rates the interaction as minor. Felodipine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol and felodipine have additive blood pressure lowering effects, which can be useful but may cause excessive hypotension, dizziness or peripheral edema. Propranolol may also modestly raise felodipine exposure.
How serious is the interaction between Felodipine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Reduce the dose of felodipine if symptomatic hypotension occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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