Drug interactions
Felodipine + Rapacuronium
Severity: Moderate
Felodipine and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can potentiate non-depolarizing neuromuscular blockers, prolonging paralysis. Rapacuronium has been withdrawn from most markets, but the principle applies to related agents.
What this interaction means in plain words
Felodipine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium channel blockade reduces presynaptic acetylcholine release, augmenting neuromuscular blockade.
What to do
Monitor neuromuscular function with a nerve stimulator and reduce blocker dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Rapacuronium?
MediHelp rates the interaction as moderate. Felodipine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers can potentiate non-depolarizing neuromuscular blockers, prolonging paralysis. Rapacuronium has been withdrawn from most markets, but the principle applies to related agents.
How serious is the interaction between Felodipine and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and reduce blocker dosing as needed.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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