Drug interactions
Felodipine + Sodium nitroprusside
Severity: Moderate
Felodipine and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is a vasodilating calcium channel blocker that adds to the blood pressure lowering of nitroprusside. The hypotensive response may be larger than expected.
What this interaction means in plain words
Felodipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Felodipine belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive arterial vasodilation through calcium channel blockade and nitric oxide-mediated relaxation.
What to do
Monitor blood pressure continuously and titrate nitroprusside to effect, using lower infusion rates if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Felodipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is a vasodilating calcium channel blocker that adds to the blood pressure lowering of nitroprusside. The hypotensive response may be larger than expected.
How serious is the interaction between Felodipine and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure continuously and titrate nitroprusside to effect, using lower infusion rates if needed.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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