Drug interactions
Felodipine + Vincristine liposomal
Severity: Minor
Felodipine and Vincristine liposomal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine may inhibit P-glycoprotein, which could increase vincristine exposure and neurotoxicity. The clinical relevance is uncertain, particularly for the liposomal formulation, whose disposition differs from free vincristine.
What this interaction means in plain words
Felodipine and Vincristine liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak P-gp inhibition by felodipine reduces efflux of vincristine; clinical significance is not established.
What to do
Monitor for peripheral neuropathy, constipation and other neurotoxicity during co-therapy. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Vincristine liposomal?
MediHelp rates the interaction as minor. Felodipine and Vincristine liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felodipine may inhibit P-glycoprotein, which could increase vincristine exposure and neurotoxicity. The clinical relevance is uncertain, particularly for the liposomal formulation, whose disposition differs from free vincristine.
How serious is the interaction between Felodipine and Vincristine liposomal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and other neurotoxicity during co-therapy. No routine dose change is required.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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