Drug interactions
Felodipine + Xipamide
Severity: Moderate
Felodipine and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and felodipine is a vasodilating calcium channel blocker, so combining them lowers blood pressure further. This is often used intentionally but may cause hypotension, dizziness or electrolyte disturbance.
What this interaction means in plain words
Felodipine and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects via diuresis/volume reduction and arterial vasodilation.
What to do
Monitor blood pressure and serum electrolytes, especially after initiation or dose changes. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Felodipine with Xipamide?
MediHelp rates the interaction as moderate. Felodipine and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and felodipine is a vasodilating calcium channel blocker, so combining them lowers blood pressure further. This is often used intentionally but may cause hypotension, dizziness or electrolyte disturbance.
How serious is the interaction between Felodipine and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum electrolytes, especially after initiation or dose changes. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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