Drug interactions
Fenbufen + Fluoxetine
Severity: Moderate
Fenbufen and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet function and NSAIDs damage gastric mucosa and inhibit platelets. Together they increase the risk of gastrointestinal and other bleeding compared with either alone.
What this interaction means in plain words
Fenbufen and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects: SSRI depletion of platelet serotonin impairs aggregation, while NSAID inhibition of cyclooxygenase reduces platelet function and gastric protection.
What to do
Avoid long-term combined use where possible; use the lowest NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fenbufen with Fluoxetine?
MediHelp rates the interaction as moderate. Fenbufen and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs impair platelet function and NSAIDs damage gastric mucosa and inhibit platelets. Together they increase the risk of gastrointestinal and other bleeding compared with either alone.
How serious is the interaction between Fenbufen and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combined use where possible; use the lowest NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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