Drug interactions
Fenbufen + Fosinopril-hydrochlorothiazide
Severity: Moderate
Fenbufen and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with fenbufen for renal tubular secretion, but the effect is likely small. More relevant, NSAIDs like fenbufen can blunt the antihypertensive and diuretic effects of ACE inhibitors and thiazides and increase renal risk.
What this interaction means in plain words
Fenbufen and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID prostaglandin inhibition reduces renal perfusion and sodium excretion, and tubular secretion competition may alter levels.
What to do
Monitor blood pressure and renal function and keep NSAID use short. Ensure adequate hydration, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fenbufen with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Fenbufen and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may compete with fenbufen for renal tubular secretion, but the effect is likely small. More relevant, NSAIDs like fenbufen can blunt the antihypertensive and diuretic effects of ACE inhibitors and thiazides and increase renal risk.
How serious is the interaction between Fenbufen and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and keep NSAID use short. Ensure adequate hydration, especially in older patients.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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