Drug interactions
Fenbufen + Hydrochlorothiazide-losartan
Severity: Moderate
Fenbufen and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, can reduce the antihypertensive effect of losartan and hydrochlorothiazide. The combination also increases the risk of acute kidney injury and hyperkalemia, particularly in older or dehydrated patients.
What this interaction means in plain words
Fenbufen and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, which blunts the antihypertensive effect and impairs glomerular filtration when angiotensin II is blocked.
What to do
Avoid prolonged NSAID use where possible; otherwise monitor blood pressure, serum creatinine and potassium and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Fenbufen with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Fenbufen and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, can reduce the antihypertensive effect of losartan and hydrochlorothiazide. The combination also increases the risk of acute kidney injury and hyperkalemia, particularly in older or dehydrated patients.
How serious is the interaction between Fenbufen and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged NSAID use where possible; otherwise monitor blood pressure, serum creatinine and potassium and ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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