Drug interactions
Fenbufen + Irbesartan
Severity: Moderate
Fenbufen and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, can reduce the antihypertensive effect of irbesartan and impair renal function, with potassium rising in susceptible patients. Risk is greatest in older, dehydrated or renally impaired patients.
What this interaction means in plain words
Fenbufen and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, adding to angiotensin receptor blockade effects on GFR and potassium.
What to do
Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Fenbufen with Irbesartan?
MediHelp rates the interaction as moderate. Fenbufen and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, can reduce the antihypertensive effect of irbesartan and impair renal function, with potassium rising in susceptible patients. Risk is greatest in older, dehydrated or renally impaired patients.
How serious is the interaction between Fenbufen and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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