Drug interactions
Fenbufen + Levofloxacin
Severity: Major
Fenbufen and Levofloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen is the NSAID best known for provoking convulsions when combined with quinolones. The combination can lower the seizure threshold, particularly in patients with epilepsy, renal impairment or older age.
What this interaction means in plain words
Fenbufen and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Biphenylacetic acid metabolite of fenbufen enhances quinolone-mediated GABA-A receptor antagonism, causing CNS excitation.
What to do
Avoid the combination and use a different NSAID or antibiotic. If co-use is unavoidable, monitor for neurological symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Fenbufen with Levofloxacin?
MediHelp rates the interaction as major. Fenbufen and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenbufen is the NSAID best known for provoking convulsions when combined with quinolones. The combination can lower the seizure threshold, particularly in patients with epilepsy, renal impairment or older age.
How serious is the interaction between Fenbufen and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a different NSAID or antibiotic. If co-use is unavoidable, monitor for neurological symptoms.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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