Drug interactions
Fenbufen + Mesalamine
Severity: Moderate
Fenbufen and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine can rarely cause interstitial nephritis and NSAIDs such as fenbufen can reduce renal perfusion and cause kidney injury. Concurrent use may increase the chance of renal impairment.
What this interaction means in plain words
Fenbufen and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with NSAID inhibition of renal prostaglandins combined with the intrinsic tubulointerstitial toxicity of mesalamine.
What to do
Monitor serum creatinine and urine output at baseline and periodically, and avoid the NSAID in patients with reduced renal function. Prefer paracetamol for analgesia when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Fenbufen with Mesalamine?
MediHelp rates the interaction as moderate. Fenbufen and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mesalamine can rarely cause interstitial nephritis and NSAIDs such as fenbufen can reduce renal perfusion and cause kidney injury. Concurrent use may increase the chance of renal impairment.
How serious is the interaction between Fenbufen and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output at baseline and periodically, and avoid the NSAID in patients with reduced renal function. Prefer paracetamol for analgesia when possible.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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