Drug interactions
Fenbufen + Milnacipran
Severity: Moderate
Fenbufen and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, causes gastric mucosal injury and platelet inhibition, while milnacipran reduces platelet serotonin. The combination increases the risk of GI and other bleeding.
What this interaction means in plain words
Fenbufen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction (SNRI serotonin depletion plus NSAID COX inhibition) with NSAID mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest duration, monitor for GI bleeding, and consider a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenbufen and Milnacipran, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Fenbufen with Milnacipran?
MediHelp rates the interaction as moderate. Fenbufen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, causes gastric mucosal injury and platelet inhibition, while milnacipran reduces platelet serotonin. The combination increases the risk of GI and other bleeding.
How serious is the interaction between Fenbufen and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest duration, monitor for GI bleeding, and consider a proton pump inhibitor in high-risk patients.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
