Drug interactions
Fenbufen + Sertraline
Severity: Moderate
Fenbufen and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs and NSAIDs each raise the risk of gastrointestinal bleeding, and together the risk is considerably higher than with either alone. The risk is greatest in older adults and those with prior ulcers or on anticoagulants or corticosteroids.
What this interaction means in plain words
Fenbufen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
SSRIs reduce platelet serotonin and aggregation while NSAIDs inhibit prostaglandin-mediated mucosal protection and platelet function.
What to do
Use the lowest effective NSAID dose for the shortest time and consider adding a proton pump inhibitor in higher-risk patients. Advise patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Fenbufen with Sertraline?
MediHelp rates the interaction as moderate. Fenbufen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs and NSAIDs each raise the risk of gastrointestinal bleeding, and together the risk is considerably higher than with either alone. The risk is greatest in older adults and those with prior ulcers or on anticoagulants or corticosteroids.
How serious is the interaction between Fenbufen and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and consider adding a proton pump inhibitor in higher-risk patients. Advise patients to report black stools or abdominal pain.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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