Drug interactions
Fenofibrate micronized + Glimepiride
Severity: Minor
Fenofibrate micronized and Glimepiride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may modestly enhance the glucose-lowering effect of sulfonylureas, with a potential for hypoglycemia. The effect is generally small and predicted rather than well documented.
What this interaction means in plain words
Fenofibrate micronized and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Fibrates may improve insulin sensitivity and possibly displace sulfonylureas from protein binding, giving additive glucose lowering.
What to do
Monitor blood glucose after starting fenofibrate and adjust the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Fenofibrate micronized with Glimepiride?
MediHelp rates the interaction as minor. Fenofibrate micronized and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fibrates may modestly enhance the glucose-lowering effect of sulfonylureas, with a potential for hypoglycemia. The effect is generally small and predicted rather than well documented.
How serious is the interaction between Fenofibrate micronized and Glimepiride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting fenofibrate and adjust the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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