Drug interactions
Fenofibrate micronized + Glyburide
Severity: Minor
Fenofibrate micronized and Glyburide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate is highly protein bound and may modestly displace sulfonylureas, with a theoretical increase in glucose-lowering effect. Clinically significant hypoglycemia is uncommon but possible, especially with low albumin.
What this interaction means in plain words
Fenofibrate micronized and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for plasma protein binding, raising free glyburide; clinical relevance is limited.
What to do
Be aware of the potential for hypoglycemia and check blood glucose in patients with hypoalbuminemia or renal impairment after starting fenofibrate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Fenofibrate micronized with Glyburide?
MediHelp rates the interaction as minor. Fenofibrate micronized and Glyburide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate is highly protein bound and may modestly displace sulfonylureas, with a theoretical increase in glucose-lowering effect. Clinically significant hypoglycemia is uncommon but possible, especially with low albumin.
How serious is the interaction between Fenofibrate micronized and Glyburide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of the potential for hypoglycemia and check blood glucose in patients with hypoalbuminemia or renal impairment after starting fenofibrate.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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