Drug interactions
Fenofibrate micronized + Simvastatin
Severity: Moderate
Fenofibrate micronized and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining fenofibrate with simvastatin increases the risk of myopathy and rhabdomyolysis through additive muscle toxicity. The risk is lower than with gemfibrozil, but remains clinically relevant.
What this interaction means in plain words
Fenofibrate micronized and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic muscle toxicity, with little pharmacokinetic interaction.
What to do
Use the combination only when there is a clear lipid benefit, at the lowest effective doses. Counsel the patient to report muscle symptoms and measure CK if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Fenofibrate micronized with Simvastatin?
MediHelp rates the interaction as moderate. Fenofibrate micronized and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining fenofibrate with simvastatin increases the risk of myopathy and rhabdomyolysis through additive muscle toxicity. The risk is lower than with gemfibrozil, but remains clinically relevant.
How serious is the interaction between Fenofibrate micronized and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination only when there is a clear lipid benefit, at the lowest effective doses. Counsel the patient to report muscle symptoms and measure CK if they appear.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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