Drug interactions
Fenofibrate micronized + Tolazamide
Severity: Minor
Fenofibrate micronized and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate may modestly enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported. The clinical significance is generally small but may matter in patients with low albumin or reduced intake.
What this interaction means in plain words
Fenofibrate micronized and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible displacement from plasma protein binding and improved insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when fenofibrate is started or stopped. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Fenofibrate micronized with Tolazamide?
MediHelp rates the interaction as minor. Fenofibrate micronized and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate may modestly enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported. The clinical significance is generally small but may matter in patients with low albumin or reduced intake.
How serious is the interaction between Fenofibrate micronized and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibrate is started or stopped. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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