Drug interactions
Fenofibrate micronized + Tolbutamide
Severity: Minor
Fenofibrate micronized and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fibrates may modestly improve glycemia and could enhance the effect of sulfonylureas, with hypoglycemia reported for the class. The evidence for fenofibrate specifically is weak.
What this interaction means in plain words
Fenofibrate micronized and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement and improved insulin sensitivity.
What to do
Monitor blood glucose when fenofibrate is started. Adjust tolbutamide only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Fenofibrate micronized with Tolbutamide?
MediHelp rates the interaction as minor. Fenofibrate micronized and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fibrates may modestly improve glycemia and could enhance the effect of sulfonylureas, with hypoglycemia reported for the class. The evidence for fenofibrate specifically is weak.
How serious is the interaction between Fenofibrate micronized and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fenofibrate is started. Adjust tolbutamide only if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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