Drug interactions
Fenofibrate micronized + Warfarin
Severity: Major
Fenofibrate micronized and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate can enhance the anticoagulant effect of warfarin and raise INR, which increases the risk of bleeding. The effect usually emerges within the first weeks of combined therapy.
What this interaction means in plain words
Fenofibrate micronized and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP2C9 and possible displacement of warfarin from plasma protein binding.
What to do
Check INR frequently when starting, changing or stopping fenofibrate. Reduce the warfarin dose as needed, as labeling advises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Fenofibrate micronized with Warfarin?
MediHelp rates the interaction as major. Fenofibrate micronized and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenofibrate can enhance the anticoagulant effect of warfarin and raise INR, which increases the risk of bleeding. The effect usually emerges within the first weeks of combined therapy.
How serious is the interaction between Fenofibrate micronized and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR frequently when starting, changing or stopping fenofibrate. Reduce the warfarin dose as needed, as labeling advises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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