Drug interactions
Fenoprofen + Fluoxetine
Severity: Moderate
Fenoprofen and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine reduces platelet serotonin and with an NSAID increases the risk of upper gastrointestinal bleeding. Fluoxetine may also inhibit CYP2C9, which could modestly raise exposure to some NSAIDs.
What this interaction means in plain words
Fenoprofen and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction from SSRI serotonin reuptake inhibition and NSAID COX inhibition, with NSAID mucosal injury.
What to do
Consider a proton pump inhibitor in at-risk patients and use the lowest effective NSAID dose. Advise patients to report GI bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fenoprofen with Fluoxetine?
MediHelp rates the interaction as moderate. Fenoprofen and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine reduces platelet serotonin and with an NSAID increases the risk of upper gastrointestinal bleeding. Fluoxetine may also inhibit CYP2C9, which could modestly raise exposure to some NSAIDs.
How serious is the interaction between Fenoprofen and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in at-risk patients and use the lowest effective NSAID dose. Advise patients to report GI bleeding signs.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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