Drug interactions
Fenoprofen + Hydrochlorothiazide-losartan
Severity: Major
Fenoprofen and Hydrochlorothiazide-losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce vasodilatory renal prostaglandins, which can blunt the antihypertensive effect of losartan and hydrochlorothiazide. In volume-depleted or elderly patients, this combination (the triple whammy of ARB, diuretic and NSAID) raises the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Fenoprofen and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis reduces renal blood flow and sodium excretion while the ARB and diuretic reduce glomerular perfusion pressure.
What to do
Avoid regular NSAID use where possible and choose paracetamol or another alternative. If needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Fenoprofen and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce vasodilatory renal prostaglandins, which can blunt the antihypertensive effect of losartan and hydrochlorothiazide. In volume-depleted or elderly patients, this combination (the triple whammy of ARB, diuretic and NSAID) raises the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Fenoprofen and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and choose paracetamol or another alternative. If needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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