Drug interactions
Fenoprofen + Imatinib
Severity: Moderate
Fenoprofen and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia, and NSAIDs impair platelet function and irritate the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Fenoprofen and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Imatinib belongs to Oncology.
Why it happens
Additive bleeding risk from imatinib-induced thrombocytopenia and NSAID platelet inhibition and mucosal injury.
What to do
Monitor platelet counts and watch for bleeding, preferring paracetamol for analgesia where possible. Avoid NSAIDs when platelets are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fenoprofen with Imatinib?
MediHelp rates the interaction as moderate. Fenoprofen and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia, and NSAIDs impair platelet function and irritate the gastric mucosa. Together they increase the risk of gastrointestinal and other bleeding.
How serious is the interaction between Fenoprofen and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and watch for bleeding, preferring paracetamol for analgesia where possible. Avoid NSAIDs when platelets are low.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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