Drug interactions
Fenoprofen + Irbesartan
Severity: Moderate
Fenoprofen and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can weaken the blood pressure lowering effect of irbesartan. In elderly, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Fenoprofen and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Irbesartan belongs to Cardiovascular.
Why it happens
NSAIDs reduce vasodilatory renal prostaglandins, lowering glomerular perfusion already dependent on angiotensin blockade, and promote sodium retention and potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium after starting the NSAID and periodically thereafter. Ensure hydration and avoid prolonged use, especially in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Fenoprofen with Irbesartan?
MediHelp rates the interaction as moderate. Fenoprofen and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can weaken the blood pressure lowering effect of irbesartan. In elderly, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Fenoprofen and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting the NSAID and periodically thereafter. Ensure hydration and avoid prolonged use, especially in high-risk patients.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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