Drug interactions
Fenoprofen + Milnacipran
Severity: Moderate
Fenoprofen and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Milnacipran inhibits serotonin reuptake into platelets, impairing platelet aggregation, and fenoprofen adds antiplatelet and mucosal-damaging effects. The combination increases the risk of bleeding, especially upper gastrointestinal bleeding.
What this interaction means in plain words
Fenoprofen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Milnacipran belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction (reduced platelet serotonin and COX-1 inhibition) plus NSAID gastric mucosal injury.
What to do
Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Prefer a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Fenoprofen with Milnacipran?
MediHelp rates the interaction as moderate. Fenoprofen and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Milnacipran inhibits serotonin reuptake into platelets, impairing platelet aggregation, and fenoprofen adds antiplatelet and mucosal-damaging effects. The combination increases the risk of bleeding, especially upper gastrointestinal bleeding.
How serious is the interaction between Fenoprofen and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Prefer a non-NSAID analgesic where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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