Drug interactions
Fenoprofen + Oxaprozin
Severity: Major
Fenoprofen and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs offers no added benefit and increases the risk of gastrointestinal bleeding and ulceration, renal injury and cardiovascular events.
What this interaction means in plain words
Fenoprofen and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive COX-1 and COX-2 inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Avoid concurrent NSAID use; select one agent at the lowest effective dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Fenoprofen with Oxaprozin?
MediHelp rates the interaction as major. Fenoprofen and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs offers no added benefit and increases the risk of gastrointestinal bleeding and ulceration, renal injury and cardiovascular events.
How serious is the interaction between Fenoprofen and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use; select one agent at the lowest effective dose.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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