Drug interactions
Fenoprofen + Pemetrexed
Severity: Major
Fenoprofen and Pemetrexed: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can raise pemetrexed exposure and increase its toxicity, including bone marrow suppression, kidney injury and gastrointestinal toxicity. The risk is greatest in patients with reduced renal function.
What this interaction means in plain words
Fenoprofen and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Why it happens
NSAID-induced reduction in renal blood flow and glomerular filtration decreases renal clearance of pemetrexed, which is mainly eliminated unchanged by the kidney.
What to do
Fenoprofen has a short half-life, so withhold it for about 2 days before, the day of, and 2 days after pemetrexed in patients with normal renal function. Avoid it in patients with mild to moderate renal impairment and monitor blood counts and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Pemetrexed
Frequently asked questions
Can I take Fenoprofen with Pemetrexed?
MediHelp rates the interaction as major. Fenoprofen and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can raise pemetrexed exposure and increase its toxicity, including bone marrow suppression, kidney injury and gastrointestinal toxicity. The risk is greatest in patients with reduced renal function.
How serious is the interaction between Fenoprofen and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Fenoprofen has a short half-life, so withhold it for about 2 days before, the day of, and 2 days after pemetrexed in patients with normal renal function. Avoid it in patients with mild to moderate renal impairment and monitor blood counts and renal function.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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