Drug interactions
Fenoprofen + Phentolamine
Severity: Minor
Fenoprofen and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as fenoprofen can cause sodium and fluid retention and blunt vasodilator responses, which may reduce the blood pressure lowering effect of phentolamine. The clinical effect is usually modest and is more relevant with sustained NSAID use.
What this interaction means in plain words
Fenoprofen and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenoprofen belongs to Musculoskeletal; Phentolamine belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis may pharmacodynamically oppose alpha-blocker-induced vasodilation.
What to do
Monitor blood pressure when fenoprofen is used regularly with phentolamine and adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenoprofen and Phentolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Phentolamine
Frequently asked questions
Can I take Fenoprofen with Phentolamine?
MediHelp rates the interaction as minor. Fenoprofen and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs such as fenoprofen can cause sodium and fluid retention and blunt vasodilator responses, which may reduce the blood pressure lowering effect of phentolamine. The clinical effect is usually modest and is more relevant with sustained NSAID use.
How serious is the interaction between Fenoprofen and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when fenoprofen is used regularly with phentolamine and adjust antihypertensive therapy if control worsens.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
