Drug interactions
Fenoprofen + Pivmecillinam
Severity: Minor
Fenoprofen and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins and NSAIDs are both organic acids that are secreted by renal tubules. NSAIDs may modestly reduce penicillin clearance, but the clinical consequence is usually small.
What this interaction means in plain words
Fenoprofen and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fenoprofen belongs to Musculoskeletal; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Competition for renal tubular anion secretion and protein binding.
What to do
No routine adjustment is needed; monitor for beta-lactam adverse effects in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Fenoprofen with Pivmecillinam?
MediHelp rates the interaction as minor. Fenoprofen and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins and NSAIDs are both organic acids that are secreted by renal tubules. NSAIDs may modestly reduce penicillin clearance, but the clinical consequence is usually small.
How serious is the interaction between Fenoprofen and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for beta-lactam adverse effects in renal impairment.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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