Drug interactions
Pivmecillinam + Probenecid
Severity: Moderate
Pivmecillinam and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal tubular secretion of mecillinam, the active form, raising and prolonging its concentrations. This is usually clinically manageable.
What this interaction means in plain words
Pivmecillinam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pivmecillinam belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular secretion of mecillinam.
What to do
Avoid the combination if possible, as it adds little benefit for uncomplicated urinary infection. Monitor for adverse effects if both are given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Pivmecillinam
Frequently asked questions
Can I take Pivmecillinam with Probenecid?
MediHelp rates the interaction as moderate. Pivmecillinam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal tubular secretion of mecillinam, the active form, raising and prolonging its concentrations. This is usually clinically manageable.
How serious is the interaction between Pivmecillinam and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, as it adds little benefit for uncomplicated urinary infection. Monitor for adverse effects if both are given.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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