Drug interactions
Pivmecillinam + Tetracycline
Severity: Moderate
Pivmecillinam and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracycline may reduce the bactericidal activity of mecillinam, a beta-lactam that requires growing bacteria. Clinical significance is uncertain and mostly theoretical.
What this interaction means in plain words
Pivmecillinam and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pivmecillinam belongs to Anti Bacterial; Tetracycline belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism between a bacteriostatic agent and a growth-dependent bactericidal beta-lactam.
What to do
Avoid concurrent use where an alternative exists. If both are needed, monitor clinical and microbiological response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Other interactions of Pivmecillinam
Frequently asked questions
Can I take Pivmecillinam with Tetracycline?
MediHelp rates the interaction as moderate. Pivmecillinam and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracycline may reduce the bactericidal activity of mecillinam, a beta-lactam that requires growing bacteria. Clinical significance is uncertain and mostly theoretical.
How serious is the interaction between Pivmecillinam and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If both are needed, monitor clinical and microbiological response.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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