Drug interactions
Fenoprofen + Potassium citrate
Severity: Moderate
Fenoprofen and Potassium citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can impair renal potassium handling and may contribute to hyperkalemia alongside potassium citrate. The risk is higher with renal insufficiency.
What this interaction means in plain words
Fenoprofen and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Potassium citrate belongs to Gastrointestinal Tract.
Why it happens
Inhibition of prostaglandin synthesis reduces renin-aldosterone activity and renal potassium excretion.
What to do
Monitor serum potassium and creatinine, especially in older or renally impaired patients. Adjust the supplement if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Potassium citrate
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Fenoprofen with Potassium citrate?
MediHelp rates the interaction as moderate. Fenoprofen and Potassium citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can impair renal potassium handling and may contribute to hyperkalemia alongside potassium citrate. The risk is higher with renal insufficiency.
How serious is the interaction between Fenoprofen and Potassium citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine, especially in older or renally impaired patients. Adjust the supplement if potassium rises.
What other medicines interact with Potassium citrate?
MediHelp also lists interactions of Potassium citrate with, for example, Triamterene, Amiloride, Amlodipine-benazepril. The full list is on the Potassium citrate page.
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