Drug interactions
Fenoprofen + Pralatrexate
Severity: Moderate
Fenoprofen and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the renal elimination of pralatrexate, raising its exposure and increasing the risk of mucositis, myelosuppression and other toxicities. The risk is greater with renal impairment.
What this interaction means in plain words
Fenoprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
NSAIDs reduce renal perfusion and may compete for renal tubular secretion, delaying pralatrexate clearance.
What to do
Monitor for pralatrexate toxicity such as mucositis and cytopenias, and check renal function. Consider avoiding the NSAID or adjusting the pralatrexate dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Fenoprofen with Pralatrexate?
MediHelp rates the interaction as moderate. Fenoprofen and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the renal elimination of pralatrexate, raising its exposure and increasing the risk of mucositis, myelosuppression and other toxicities. The risk is greater with renal impairment.
How serious is the interaction between Fenoprofen and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pralatrexate toxicity such as mucositis and cytopenias, and check renal function. Consider avoiding the NSAID or adjusting the pralatrexate dose as needed.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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