Drug interactions
Fenoprofen + Prasugrel
Severity: Major
Fenoprofen and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prasugrel is a potent antiplatelet agent and NSAIDs add platelet inhibition and gastric mucosal injury. Together they raise the risk of serious bleeding, particularly gastrointestinal.
What this interaction means in plain words
Fenoprofen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive platelet inhibition (P2Y12 blockade plus reversible COX-1 inhibition) with NSAID mucosal damage.
What to do
Avoid chronic NSAID use with prasugrel; use paracetamol where possible. If unavoidable, add a proton pump inhibitor and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Fenoprofen with Prasugrel?
MediHelp rates the interaction as major. Fenoprofen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prasugrel is a potent antiplatelet agent and NSAIDs add platelet inhibition and gastric mucosal injury. Together they raise the risk of serious bleeding, particularly gastrointestinal.
How serious is the interaction between Fenoprofen and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic NSAID use with prasugrel; use paracetamol where possible. If unavoidable, add a proton pump inhibitor and monitor for bleeding.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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