Drug interactions
Fenoprofen + Probenecid
Severity: Moderate
Fenoprofen and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can raise fenoprofen plasma concentrations, increasing the risk of NSAID adverse effects such as gastrointestinal and renal toxicity. Fenoprofen may also modestly affect probenecid handling, and the uricosuric effect can be blunted by salicylates but is less affected by most other NSAIDs.
What this interaction means in plain words
Fenoprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular organic anion transport and glucuronidation, reducing fenoprofen clearance.
What to do
Consider a lower fenoprofen dose and monitor for NSAID adverse effects such as dyspepsia, GI bleeding and renal dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fenoprofen and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Fenoprofen with Probenecid?
MediHelp rates the interaction as moderate. Fenoprofen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can raise fenoprofen plasma concentrations, increasing the risk of NSAID adverse effects such as gastrointestinal and renal toxicity. Fenoprofen may also modestly affect probenecid handling, and the uricosuric effect can be blunted by salicylates but is less affected by most other NSAIDs.
How serious is the interaction between Fenoprofen and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower fenoprofen dose and monitor for NSAID adverse effects such as dyspepsia, GI bleeding and renal dysfunction.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
