Drug interactions
Fenoprofen + Sertraline
Severity: Moderate
Fenoprofen and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID substantially raises the risk of upper gastrointestinal bleeding compared with either drug alone. The risk is greater in older adults and those with prior ulcers.
What this interaction means in plain words
Fenoprofen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation while NSAIDs inhibit platelet thromboxane and damage gastric mucosa.
What to do
Consider a proton pump inhibitor for gastroprotection in at-risk patients and use the lowest NSAID dose for the shortest time. Counsel patients to report black stools or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Fenoprofen with Sertraline?
MediHelp rates the interaction as moderate. Fenoprofen and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID substantially raises the risk of upper gastrointestinal bleeding compared with either drug alone. The risk is greater in older adults and those with prior ulcers.
How serious is the interaction between Fenoprofen and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection in at-risk patients and use the lowest NSAID dose for the shortest time. Counsel patients to report black stools or hematemesis.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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