Drug interactions
Fenoprofen + Sparsentan
Severity: Major
Fenoprofen and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan lowers glomerular pressure through endothelin and angiotensin receptor blockade, and NSAIDs constrict afferent arterioles. Combined use can worsen kidney function, particularly in volume-depleted or older patients, and may blunt blood pressure control.
What this interaction means in plain words
Fenoprofen and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan blocks efferent arteriolar tone while NSAIDs inhibit prostaglandin-mediated afferent dilation, together sharply reducing glomerular filtration.
What to do
Avoid regular NSAID use in patients on sparsentan and choose an alternative analgesic such as paracetamol. If unavoidable, monitor serum creatinine, potassium and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Fenoprofen with Sparsentan?
MediHelp rates the interaction as major. Fenoprofen and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan lowers glomerular pressure through endothelin and angiotensin receptor blockade, and NSAIDs constrict afferent arterioles. Combined use can worsen kidney function, particularly in volume-depleted or older patients, and may blunt blood pressure control.
How serious is the interaction between Fenoprofen and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in patients on sparsentan and choose an alternative analgesic such as paracetamol. If unavoidable, monitor serum creatinine, potassium and blood pressure closely.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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